Bupropion is a NDRI. Then you would have to add on an SSRI. However, 2 antidepressants aren’t usually prescribed together.

Edit: dextromethorphan/bupropion (brand name Auvelity). The dextromethorphan hits multiple targets including NMDA and sigma 1, but technically has some inhibition activity to SERT. I am unsure how strong that activity is, whether it is dose dependant, if its an active metabolite etc. Also should point out that nowhere on the manufacturers website do they talk about using the dextromethorphan to hit serotonin. According to the website, the true mechanism of action of Auvelity for treating MDD is not well understood.

Edit2: check out this page. Gives more info and some references. Apparently fairly strong against SERT. [(https://tmedweb.tulane.edu/pharmwiki/doku.php/dextromethorphan)]

https://theneedledrop.com/ check out the reviews and the loved list. Also, I’ll Shazam songs I like and look them up later.

Hi, pharmacist here. I wanted to clarify that the “discontinuation” you saw on the FDA website regarding sertraline does not mean the drug has been taken off the market. It simply indicates that one manufacturer—Strides Pharma Inc.—has recently stopped producing all strengths of sertraline tablets (25 mg, 50 mg, and 100 mg).

Sertraline is a widely used generic medication, and many other manufacturers continue to produce it.

Pokemon Blue on Gameboy

Dave Stewart covering Zombie by The Cranberries https://youtu.be/1iDTYnxCNXM

I renewed my US passport about 6 months ago. I was eligible to renew online. Cost around $130 if I remember correctly. The online process was actually really easy and it came in the mail only a few weeks later (2-3 weeks). Highly recommend renewing online if you meet the eligibility requirements.

Lol ya and all that video footage is owned by the company of those cameras, like Ring aka Amazon. They can access it at anytime and they can even give it to the police.

Edit: there are setups in which you can store your footage on your own drives. However, many people don’t know how to set it up so they use out of the box camera + app which stores all the data on the company servers.

Damn that sucks if true. I really do feel bad for them, but like what is the point of me donating if he’s not going to speak out against this administration. Doesn’t he realize it’s not just about his situation, but for everyone else who’s also impacted by this? I rather give to another family that will not only use these funds to hopefully turn their situation around but also you know like then also give back/help others and speak out. To be honest I didn’t look into OP’s comment to fact check because you know I’m only human, busy and got problems of my own. If true though this is really sad …

[Rhubarb] Aphex Twin

I believe this meme is referencing JD Vance speech at Munich Security Conference

Milf manor

“There are very few people in the history of the US healthcare industry who had a bigger positive effect on American healthcare than Brian [Thompson].”

Lol you fucking shitting me? This guy’s whole speech is a lie.

Guild Wars (the original) Just so nostalgic to me. Gameplay is fun even after all these years.

Don’t do it

100%

Warm Apple crisp with a scoop of vanilla ice cream on top!