I tried it with a 4 bay USB 3.2 chassis over USC-C using zfs raidz, constantly had issues with the array just dying and needing to bring it back online manually many times per day. It never got better and latency was an issue too.
Move all drives to a single 8 port pcie card and it worked without issue for years.
Not worth the hassle and expense.
Even though it’s an old game, Tachyon The Fringe is a great space shooter, it’s available on GOG and well worth it.
https://www.gog.com/en/game/tachyon_the_fringe